Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CHR-6494 TFA [1458630-17-5]
Cat# T9521-2mg
Size : 2mg
Brand : TargetMol
CHR-6494 TFA
Catalog No. T9521 CAS 1458630-17-5
CHR-6494 TFA is a potent haspin inhibitor, with an IC50 of 2 nM. It inhibits histone H3T3 phosphorylation. CHR-6494 TFA induces the apoptosis of cancer cells, including melanoma and breast cancer. CHR-6494 TFA can be used in the research of cancer
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CHR-6494 TFA, CAS 1458630-17-5
| Description | CHR-6494 TFA is a potent haspin inhibitor, with an IC50 of 2 nM. It inhibits histone H3T3 phosphorylation. CHR-6494 TFA induces the apoptosis of cancer cells, including melanoma and breast cancer. CHR-6494 TFA can be used in the research of cancer |
| Targets&IC50 | Haspin:2 nM (IC50) |
| In vitro | Administration of CHR-6494 (TFA; 0-10-5?nM; 72 hours) dose-dependently inhibits the growth of cancer cells, such as HCT-116, HeLa, MDA-MB-231, and Wi-38 cells, with an IC50s of 500?nM, 473?nM, 752?nM and 1059 nM, respectively[1]. Administration of CHR-6494 (TFA; 500 nM) produces a mitotic catastrophe with abnormal morphology of the mitotic spindle and centrosome amplification, and upregulates the spindle assembly checkpoint protein BUB1 and the marker of mitotic arrest cyclin B1[1]. |
| In vivo | Administration of CHR-6494 (TFA; 50?mg/kg; i.p. in two cycles of five consecutive days for 15 days) inhibits the growth of tumor and no obvious body weight change is observed in nude mice bearing HCT-116 human colorectal cancer cells[1]. |
| Molecular Weight | 406.36 |
| Formula | C18H17F3N6O2 |
| CAS No. | 1458630-17-5 |
Storage
Solubility Information
DMSO: 55 mg/mL (135.35 mM)
References and Literature
Dose Conversion
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Tech Support
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Keywords
CHR-6494 TFA 1458630-17-5 Others CHR-6494 inhibit apoptosis Haspin Kinase NRAS mutant melanoma cells CHR 6494 mitotic catastrophe Inhibitor mice CHR6494 cancer cells CHR6494 TFA BRAFV600E mutant melanoma cells CHR 6494 TFA inhibitor