Maackia amurensis (Amur maackia) Lectin (MAL)

Maackia amurensis (Amur maackia) Lectin (MAL)


Maackia amurensis lectins are leucoagglutinins or mitogenic isolectins from Maackia seeds. These lectins are used as glycoanalytical tools to probe biological targets for alpha 2-3-linked sialic acids and have a molecular weight of 13à kDa and an isoelectric point of pH 4.7.
There are 2 MAL lectins : MAL I and II. MAL I+II can be used to detect glycans containing  alpha 2-3-linked sialic acids but cannot be used to determine if the binding target is an N- or O-linked glycan. Binding assays must include sialidase-treated controls, that will greatly reduce or eliminate the lectin-binding signal to show specificity. Sialidase treatment has no impact on non-specific lectin-protein interactions or on MAL I or MAL II binding to glycans containing SO4-3-Gal.

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