Reagents and instruments for immunology, cell biology and molecular biology.
 
> Acephate [30560-19-1]

Acephate [30560-19-1]

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Cat# HY-B0841-50mg

Size : 50mg

Brand : MedChemExpress

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Description

Acephate is a broad-spectrum anticholinesterase insecticide. Acephate acts via inhibiting AChE (Cholinesterase (ChE)) activity of insects. Acephate is used for control of several species of insects in agriculture and in horticulture[1].

IC50 & Target

AChE

 

In Vitro

In rat immature Leydig cells after 3-h culture, Acephate inhibits basal androgen output in a dose-dependent manner with the inhibition starting at 0.5 μM. Acephate significantly inhibits luteinizing hormone and 8-Br-cAMP stimulated androgen output at 50 μM. Acephate significantly inhibits progesterone-mediated androgen output at 50 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Acephate Related Antibodies
In Vivo

Adult male mice are gavaged with 0, 7, 14, and 28 mg/kg/day acephate for 28 d and sperm motility and number are decreased at 14 and 28 mg/kg/day[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

183.17

Formula

C4H10NO3PS
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O=P(SC)(NC(C)=O)OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (682.43 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.4594 mL 27.2970 mL 54.5941 mL
5 mM 1.0919 mL 5.4594 mL 10.9188 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (545.94 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

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