Mouse Monoclonal Anti-Macrophage L1 Protein (Clone MAC387)
Cat# 24-6279-MSM1-500ul
Size : 500ul
Brand : American Research Products
Anti-Macrophage L1 Protein, Monoclonal Antibody
Category: Antibodies
Catalog
24-6279-MSM1
| Product Name | Anti-Macrophage L1 Protein, Monoclonal Antibody |
|---|---|
| Description | Recognizes the L1 or Calprotectin molecule, an intra-cytoplasmic antigen comprising of a 12kDa alpha chain and a 14kDa beta chain expressed by granulocytes, monocytes and by tissue macrophages. Macrophages usually arise from hematopoietic stem cells in the bone marrow. Under migration into tissues, the monocytes undergo further differentiation to become multifunctional tissue macrophages. They are classified into normal and inflammatory macrophages. Normal macrophages include macrophages in connective tissue (histiocytes), liver (Kupffer_Ûªs cells), lung (alveolar macrophages), lymph nodes (free and fixed macrophages), spleen (free and fixed macrophages), bone marrow (fixed macrophages), serous fluids (pleural and peritoneal macrophages), skin (histiocytes, Langerhans's cell) and in other tissues. Inflammatory macrophages are present in various exudates. Macrophages are part of the innate immune system, recognizing, engulfing and destroying many potential pathogens including bacteria, pathogenic protozoa, fungi and helminthes. This monoclonal antibody reacts with neutrophils, monocytes, macrophages, and squamous mucosal epithelia and has been shown as an important marker for identifying macrophages in tissue sections. |
| Synonyms | 60B8AG, Calgranulin A (CAGA), Calgranulin B (CAGB), Calprotectin L1L subunit, Chemotactic cytokine CP-10, Cystic fibrosis antigen (CFAG), Leukocyte L1 complex light chain, L1Ag, Macrophage L1 protein Calprotectin, Migration inhibitory factor related protein 8, Myeloid-related protein 8 (MRP-8 or P8), Myeloid-related protein 14 (MRP-14 or P14), Neutrophil cytosolic 7kDa protein, NIF, p8, Migration inhibitory factor related protein 14, S100 calcium binding protein A8 (S100A8), S100 calcium binding protein A9 (S100A9), S100A8/S100A9 complex, MA387, Pro-inflammatory S100 cytokine, Urinary stone protein band A |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | MAC387 |
| Immunogen | Affinity purified monocyte membrane preparation |
| Isotype | IgG1, kappa |
| Reactivity | Bovine, Canine, Equine, Feline, Goat, Guinea Pig, Human, Mouse, Porcine, Primate, Rabbit, Rat |
| Applications | FC, IF, IHC |
| Form | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 1mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Gene Id | 6279 (S100A8/Calgranulin A/MRP-8) & 6280 (S100A9/Calgranulin B/MRP-14) |
| Uniprot | P05109 (S100A8/Calgranulin A/MRP-8) & P06702 (S100A9/Calgranulin B/MRP-14) |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References | Flavell DJ; Jones DB; Wright DH. Identification of tissue histiocytes on paraffin sections by a new monoclonal antibody. Journal of Histochemistry and Cytochemistry, 1987, 35(11):1217-26 |
| Supplier | ARP |
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