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> Stemfactor LIF, Mouse Recombinant

Stemfactor LIF, Mouse Recombinant

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Cat# 03-0011

Size : 1ml,10μg/ml

Brand : ReproCELL


Stemfactor™ LIF, Mouse Recombinant

03-0011 / 03-0011-100

Brand: Stemfactor

Mouse LIF is a lymphoid factor that promotes long-term maintenance of the pluripotency of mouse PSCs by suppressing spontaneous differentiation.

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Product Information

Mouse LIF is a lymphoid factor that promotes long-term maintenance of the pluripotency of mouse embryonic stem cells by suppressing spontaneous differentiation1,2. Leukemia Inhibitory Factor (LIF) has additional functions such as cholinergic neuron differentiation, bone and fat metabolism, mitogenesis of certain factor-dependent cell lines and promotion of megakaryocyte production in vivo. Mouse LIF is an approximate 20 kDa protein containing 202 amino acid residues.

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Stemgent and the Stemfactor brand name are trademarks of REPROCELL Inc., Japan.

Safety Data Sheets:

  • Niwa, H., Ogawa, K., Shimosato, D., and Adachi, K.) A parallel circuit of LIF signalling pathways maintains pluripotency of mouse ES cells. Nature 460: 118-122 (2009).

  • Xu, J., Wang, F., Tang, Z., Zhan, Y., Zhang, J., Yan, Q., Xiong, Y., Xie, X., Wu, J., and Zhang, S. Role of leukaemia inhibitory factor in the induction of pluripotent stem cells in mice. Cell Biol Int 34: 791-797 (2010).
  • Fukunaga, N., Teramura, T., Onodera, Y., Takehara, T., Fukuda, K., and Hosoi, Y. Leukemia inhibitory factor (LIF) enhances germ cell differentiation from primate embryonic stem cells. Cell Reprogram 12: 369-376(2010).
  • Metcalf D. The unsolved enigmas of leukemia inhibitory factor. Stem Cells 21: 5-14 (2003).
  • Williams, R.L., Hilton, D.J., Pease, S., Willson, T.A., Stewart, C.L., Gearing, D.P., Wagner, E.F., Metcalf, D., Nicola, N.A., and Gough, N.M. Myeloid leukemia inhibitory factor maintains the developmental potential of embryonic stem cells. Nature 336: 684-687(1988).
  • Metcalf, D., Hilton, D.J., and Nicola, N.A. Clonal analysis of the actions of the murine leukemia inhibitory factor on leukemic and normal murine hemopoietic cells. Leukemia 2: 216-221(1988).

    • Additional Publications

    • Kim B; So S; Choi J; Kang E; Lee Y. Efficient method for generating homozygous embryonic stem cells in mice. J Animal Reproduction Biotech 37:48 (2022).
    • Huang G; Yan H; Ye S; Tong C; Ying Q-L. STAT3 Phosphorylation at Tyrosine 705 and Serine727 Deferentially Regulates Mouse ESC Fates. Stem Cells 32:1149-1160 (2014).
    • Ying, Q., Tai, C. Gbx2, a LIF/Stat3 target, promotes reprogramming to and retention of the pluripotent ground state. Journal of Cell Science 126, 1093 — 1098 (2013).