Biomimesys® Brain : A natural hydroscaffold for 3D culture of neuronal cells

Biomimesys® Brain : A natural hydroscaffold for 3D culture of neuronal cells

To better mimic the tissue microenvironment and to permit long term culture of neuronal cells

BIOMIMESYS® hydroscaffold 3D is the only ready to use hydroscaffold based on Hyaluronic Acid  (HA) and extracellular matrix compound.

BIOMIMESYS® Brain is physiological

BIOMIMESYS® Brain is a unique ready to use biofunctionalized Hyaluronic Acid (HA) hydroscaffold suitable for neuronal cell culture. BIOMIMESYS® Brain is created by double crosslinking reaction of components of brain extracellular matrix: collagen IV, cell binding domain of fibronectin (RGDS), cationic bioplolymer and Hyaluronic acid.

With the aim of better mimicking the structural properties of brain, BIOMIMESYS® Brain is made up of 80%empty volume and with a high porosity around 170µm.

BIOMIMESYS® Brain provides also enough space for gas, medium and nutrients flow circulation of fragile neuronal cell with cell-cell and cells-matrix interactions, along with a mechanical support required for an easy handling of hydroscaffold.

Spheroid dopaminergic neurons (Luhmes) in BIOMIMESYS® Brain :
Blue: nucleus, green: b3-tubulin

BIOMIMESYS® Brain  is ready-to-use 

  • Available in a ready-to-use format (96 well plates) it enables the culture of neuronal cells under physiological conditions that are representative of the tissue microenvironment.
  • Cells are simply seeded on top of the hydroscaffold and placed in the incubator
  • The media can be refreshed easily by pipetting.

BIOMIMESYS®  is compatible with all anatycal technologies

TRANSPARENT : Microscopy and plate reader

POROUS : PCR, Western Blot, ELISA

BIODEGRADABLE : Flow cytometry

SOLID : Histology and in vivo transplantation