Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BIBO3304 TFA [191868-14-1]
Cat# T10539-100mg
Size : 100mg
Brand : TargetMol
BIBO3304 TFA
Catalog No. T10539 CAS 191868-14-1
BIBO3304 TFA is an effective, orally active, and selective neuropeptide Y (NPY) Y1 receptor antagonist (IC50:0.38 and 0.72 nM for the human and the rat Y1 receptor).
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BIBO3304 TFA, CAS 191868-14-1
| Description | BIBO3304 TFA is an effective, orally active, and selective neuropeptide Y (NPY) Y1 receptor antagonist (IC50:0.38 and 0.72 nM for the human and the rat Y1 receptor). |
| Targets&IC50 | NPYY1 receptor:0.38 nM(human), NPYY1 receptor:0.72 nM (rat) |
| In vivo | BIBO3304 TFA (15-60 μg) dose-dependently inhibits the feeding response mediated by 1 μg NPY. BIBO3304 TFA (30 μg; bilateral paraventricular nucleus injection) attenuates the hyperphagia following fasting [1]. BIBO3304 TFA (0.5?μM; p.o.) significantly increases serum insulin levels [2]. |
| Molecular Weight | 643.66 |
| Formula | C31H36F3N7O5 |
| CAS No. | 191868-14-1 |
Storage
Solubility Information
DMSO: 100 mg/mL (155.36 mM), Sonication is recommended.
References and Literature
1. Wieland HA, et al. Subtype selectivity of the novel nonpeptide neuropeptide Y Y1 receptor antagonist BIBO 3304 and its effect on feeding in rodents. Br J Pharmacol. 1998 Oct;125(3):549-55. 2. Loh K, et al. Inhibition of Y1 receptor signaling improves islet transplant outcome. Nat Commun. 2017 Sep 8;8(1):490.