- Specifications
Product Description
Rat monoclonal antibody raised against recombinant IL5.
Immunogen
Recombinant protein corresponding to human IL5.
Host
Rat
Reactivity
Human
Specificity
human Interleukin-5 (IL-4)1-4.
Form
Liquid
Conjugation
Biotin
Isotype
IgG2a, kappa
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Applications
Sandwich ELISA
- Gene Info — IL5
Entrez GeneID
3567Gene Name
IL5
Gene Alias
EDF, IL-5, TRF
Gene Description
interleukin 5 (colony-stimulating factor, eosinophil)
Omim ID
147850Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. This cytokine is a main regulator of eosinopoiesis, eosinophil maturation and activation. The elevated production of this cytokine is reported to be related to asthma or hypereosinophilic syndromes. The receptor of this cytokine is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene, together with those for interleukin 4 (IL4), interleukin 13 (IL13), and CSF2, form a cytokine gene cluster on chromosome 5. This cytokine, IL4, and IL13 are found to be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. [provided by RefSeq
Other Designations
B cell differentiation factor I|OTTHUMP00000065830|T-cell replacing factor|eosinophil differentiation factor|interleukin 5|interleukin-5
- Interactomes
- Pathways
- Diseases
- Publication Reference
- Strategies of anti-cytokine monoclonal antibody development: immunoassay of IL-10 and IL-5 in clinical samples.
Abrams JS, Roncarolo MG, Yssel H, Andersson U, Gleich GJ, Silver JE.
Immunological Reviews 1992 Jun; 127:5.
- Interleukin-5 and the posttreatment eosinophilia in patients with onchocerciasis.
Limaye AP, Abrams JS, Silver JE, Awadzi K, Francis HF, Ottesen EA, Nutman TB.
The Journal of Clinical Investigation 1991 Oct; 88(4):1418.
- Interleukin-5 is a human basophilopoietin: induction of histamine content and basophilic differentiation of HL-60 cells and of peripheral blood basophil-eosinophil progenitors.
Denburg JA, Silver JE, Abrams JS.
Blood 1991 Apr; 77(7):1462.
Application：ELISA, Human, HL-60 cells.
- Strategies of anti-cytokine monoclonal antibody development: immunoassay of IL-10 and IL-5 in clinical samples.
IL5 monoclonal antibody, clone JES1-5A10 (Biotin)
Cat# MAB5869
Size : 500ug