Mouse ASPN (Asporin) Sandwich ELISA Kit Ready-To-Use

Cat# NB-22-68079-96

Size : 96T

Brand : Neo Biotech


  • Mouse ASPN (Asporin) Sandwich ELISA Kit Ready-To-Use

General Info

Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.059ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This ASPN Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs

Information

Gene Symbol: Aspn
Gene ID: 66695
Uniprot ID: ASPN_MOUSE
Immunogen Region: Ready-To-Use
Sample Type: serum, plasma, tissue homogenates or other biological fluids.

Description

Tissue Specificity Higher expression in heart, also detected in kidney, stomach, testes, and skin but only weakly in lung, skeletal muscle, small intestine, and thymus. Expressed specifically and predominantly in the periodontal ligament (PDL). During tooth development, strong expression is seen in the dental follicle, which is the progenitor tissue that forms cementum, alveolar bone, and the PDL. Expressed in the perichondria of the maxilla, mandible, vertebrae, and long bones. Predominantly expressed in the perichondrium/periosteum of long bones (at protein level).
Post Translational Modifications
Function Binds calcium and plays a role in osteoblast-driven collagen biomineralization activity. Critical regulator of TGF-beta in articular cartilage and plays an essential role in cartilage homeostasis and osteoarthritis (OA) pathogenesis. Negatively regulates chondrogenesis in the articular cartilage by blocking the TGF-beta/receptor interaction on the cell surface and inhibiting the canonical TGF-beta/Smad signal. Negatively regulates periodontal ligament (PDL) differentiation and mineralization to ensure that the PDL is not ossified and to maintain homeostasis of the tooth-supporting system. Inhibits BMP2-induced cytodifferentiation of PDL cells by preventing its binding to BMPR1B/BMP type-1B receptor, resulting in inhibition of BMP-dependent activation of SMAD proteins. Inhibits the interaction between TGFB1 and TGF-beta receptor type II in the presence of heparin/heparan sulfate in vitro.
Protein Name Asporin
Periodontal Ligament-Associated Protein 1
Plap-1
Database Links
Cellular Localisation Secreted
Extracellular Space
Extracellular Matrix
Alternative ELISA Names Asporin ELISA kit
Periodontal Ligament-Associated Protein 1 ELISA kit
Plap-1 ELISA kit
Aspn ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance