- More Files
Neutralization
Western blot shows binding reaction of PDCD1 humanized recombinant monoclonal antibody (Cat # RAB02653) and recombinant human PD1 (with Fc tag). Recombinant human PD1 (Fc) was electrophoresed by SDS-PAGE and transferred on PVDF membrane. PVDF membrane was probed with PD1 monoclonal antibody (Humanized) followed by HRP-conjugated Anti-Human IgG Fab secondary Antibody.
- Specification
Product Description
Human recombinant monoclonal antibody raised against human PDCD1.
Antibody Species
Human
Immunogen
Variable region genes (including VH &VL) of this antibody were derived from a single B cell by PCR.
Theoretical MW (kDa)
32
Reactivity
Human
Specificity
This antibody detects endogenous levels of human PD1 protein.
Form
Liquid
Purification
Protein A purification
Isotype
IgG
Recommend Usage
Neutralization
Blocking
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS with 50% Glycerol
Storage Instruction
Store at 4°C short term.
Aliquot and store at -20°C long term.
Avoid freeze-thaw cycles. - Applications
Blocking
Neutralization
Western blot shows binding reaction of PDCD1 humanized recombinant monoclonal antibody (Cat # RAB02653) and recombinant human PD1 (with Fc tag). Recombinant human PD1 (Fc) was electrophoresed by SDS-PAGE and transferred on PVDF membrane. PVDF membrane was probed with PD1 monoclonal antibody (Humanized) followed by HRP-conjugated Anti-Human IgG Fab secondary Antibody. - Gene Info — PDCD1
Entrez GeneID
5133Protein Accession#
Q15116Gene Name
PDCD1
Gene Alias
CD279, PD1, SLEB2, hPD-1, hPD-l
Gene Description
programmed cell death 1
Gene Ontology
HyperlinkGene Summary
This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq
Other Designations
-
- Interactome
- Pathway
- Disease