Zanamivir [139110-80-8]
Cat# HY-13210-50mg
Size : 50mg
Brand : MedChemExpress
Zanamivir is an influenza viral neuraminidase inhibitor with IC50 values of 0.95 nM and 2.7 nM for influenza A and B, respectively.
For research use only. We do not sell to patients.
Zanamivir Chemical Structure
CAS No. : 139110-80-8
This product is a controlled substance and not for sale in your territory.
Based on 6 publication(s) in Google Scholar
Other Forms of Zanamivir:
- Zanamivir (hydrate)(5:1) Get quote
| Description |
Zanamivir is an influenza viral neuraminidase inhibitor with IC50 values of 0.95 nM and 2.7 nM for influenza A and B, respectively. |
IC50 & Target |
IC50: 0.95 nM (Influenza A); 2.7 nM (Influenza B)[1] |
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| In Vitro |
Zanamivir interacts with a group of amino acids in the active site of neuraminidase, which are conserved in all influenza A and B strains. Zanamivir blocks the action of neuraminidase, which prevents the cleavage of sialic acid on the cell receptors, thus preventing release and spread of the newly formed virions[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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| In Vivo |
Zanamivir has a poor bioavailability in oral administration, with only 4–17% of the agent. Oral delivery of zanamivir has been a problem due to its strong hydrophilic nature that limits its transport across the intestinal epithelium. Permeation enhancers such as sodium cholate, hydroxypropyl β-cyclodextrin could be used with zanamivir to enhance the intestinal permeability[3]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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| Clinical Trial |
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| Molecular Weight |
332.31 |
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| Formula |
C12H20N4O7 |
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| CAS No. |
139110-80-8 |
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| Appearance |
Solid |
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| Color |
White to off-white |
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| SMILES |
NC(N[C@@H]1[C@H]([C@@](15)(OC(C(O)=O)=C1)[C@@H]([C@@H](CO)O)O)NC(C)=O)=N |
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| Shipping | Room temperature in continental US; may vary elsewhere. |
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| Storage |
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| Solvent & Solubility |
In Vitro:
H2O : ≥ 33.33 mg/mL (100.30 mM) *"≥" means soluble, but saturation unknown. Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles. * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
For the following dissolution methods, please prepare the working solution directly.
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration:
mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
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| Purity & Documentation |
Purity: 99.92% |
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| References |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O | 1 mM | 3.0092 mL | 15.0462 mL | 30.0924 mL | 75.2310 mL |
| 5 mM | 0.6018 mL | 3.0092 mL | 6.0185 mL | 15.0462 mL | |
| 10 mM | 0.3009 mL | 1.5046 mL | 3.0092 mL | 7.5231 mL | |
| 15 mM | 0.2006 mL | 1.0031 mL | 2.0062 mL | 5.0154 mL | |
| 20 mM | 0.1505 mL | 0.7523 mL | 1.5046 mL | 3.7615 mL | |
| 25 mM | 0.1204 mL | 0.6018 mL | 1.2037 mL | 3.0092 mL | |
| 30 mM | 0.1003 mL | 0.5015 mL | 1.0031 mL | 2.5077 mL | |
| 40 mM | 0.0752 mL | 0.3762 mL | 0.7523 mL | 1.8808 mL | |
| 50 mM | 0.0602 mL | 0.3009 mL | 0.6018 mL | 1.5046 mL | |
| 60 mM | 0.0502 mL | 0.2508 mL | 0.5015 mL | 1.2538 mL | |
| 80 mM | 0.0376 mL | 0.1881 mL | 0.3762 mL | 0.9404 mL | |
| 100 mM | 0.0301 mL | 0.1505 mL | 0.3009 mL | 0.7523 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.