Anti-MHC Class I (H-2 class I histocompatibility antigen, K-B alpha chain precursor, H-2 Class I histocompatibility antigen, K-D alpha chain precursor, H-2 class I histocompatibility antigen, K-K alpha chain precursor, H-2 class I histocompatibility antigen, K-Q alpha chain, H-2 class I histocompatibility antigen, K-W28 alpha chain precursor, H2-K, H-2K, H-2K(B), H-2K(d), H-2K(D), H-2K(K), H-2K(Q), MGC7052, MHC I) Monoclonal Antibody

The primary immunological function of MHC molecules is to bind and present antigenic peptides on the surfaces of cells for recognition by the antigen-specific T cell receptors (TCRs) of lymphocytes. MHC class I molecules are expressed on the surfaces of most cells and are recognized by CD8-positive cytotoxic T-cells, an essential step for initiating the elimination of virally infected cells by T-cell-mediated lysis. MHC class I molecules are heterodimers composed of an alpha (44kD) and a beta (beta microglobulin, 11kD) subunit. The first two structural domains of the alpha subunit associate to form the peptide-binding pocket. ||Applications:|Suitable for use in Flow Cytometry and Immunohistochemistry. |Other applications not tested.||Recommended Dilutions:|Flow Cytometry: 1:50|Immunohistochemistry (frozen): 1:50|The antigen is glutaraldehyde (0.05%) and paraformaldehyde (1%) resistant. |Optimal dilutions to be determined by the researcher.||Storage and Stability:|May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.