SLC6A7/PROT Polyclonal Antibody, Biotin Conjugated
Cat# bs-12124R-Biotin
Size : 100ul
Brand : Bioss
SLC6A7/PROT Polyclonal Antibody, Biotin Conjugated
Applications
Predicted Reactivity
Overview | |
Catalog # | bs-12124R-Biotin |
Product Name | SLC6A7/PROT Polyclonal Antibody, Biotin Conjugated |
Applications | ELISA, IHC-P, IHC-F |
Predicted Reactivity | Human, Mouse, Rat, Dog, Cow, Sheep, Pig, Horse, Chicken |
Specifications | |
Conjugation | Biotin |
Host | Rabbit |
Source | KLH conjugated synthetic peptide derived from human SLC6A7/PROT |
Immunogen Range | 151-260/636 |
Clonality | Polyclonal |
Isotype | IgG |
Concentration | 1ug/ul |
Purification | Purified by Protein A. |
Storage Buffer | Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
Storage Condition | Store at -20°C for 12 months. |
Target | |
Subcellular location | Cell membrane |
Synonyms | SC6A7_HUMAN; Slc6a7; Sodium-dependent proline transporter; Solute carrier family 6 member 7. |
Background | The GAT1 gene family includes sodium- and chloride-dependent plasma membrane transporters for neurotransmitters, metabolites and osmolites, which couple substrate flux to transmembrane electrochemical gradients. PROT (Sodium-dependent proline transporter), also known as Solute carrier family 6 member 7, is a 636 amino acid multi-pass membrane protein that is a GAT1 family member specifically expressed in regions of the brain. PROT terminates the action of proline by its high affinity sodium/chloride-dependent reuptake into pre-synaptic terminals. Enriched in glutamatergic synaptic terminals, it is likely that PROT plays an important role in excitatory events of neurotransmission. PROT-mediated proline uptake is inhibited by compounds such as benztropine, LP-403812 and Des-Tyr-Leu-enkephalin (GGFL). These inhibitors of proline uptake may lead to the development of therapeutic agents for certain neurologic disorders. |
Application Dilution | |
ELISA | 1:500-1000 |
IHC-P | 1:200-400 |
IHC-F | 1:100-500 |