Remdesivir O-desphosphate acetonide impurity [1191237-80-5]
Cat# HY-136597-1ml
Size : 10mM/1mL
Brand : MedChemExpress
Remdesivir O-desphosphate acetonide impurity is an impurity of Remdesivir. Remdesivir (GS-5734), a nucleoside analogue with effective antiviral activity and is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro.
For research use only. We do not sell to patients.
Remdesivir O-desphosphate acetonide impurity Chemical Structure
CAS No. : 1191237-80-5
This product is a controlled substance and not for sale in your territory.
Based on 2 publication(s) in Google Scholar
Description |
Remdesivir O-desphosphate acetonide impurity is an impurity of Remdesivir. Remdesivir (GS-5734), a nucleoside analogue with effective antiviral activity and is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro[1][2]. |
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In Vitro |
Remdesivir O-desphosphate acetonide impurity (analogue 21) is a 2′,3′-acetonide protected analogue of Remdesivir[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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Molecular Weight |
331.33 |
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Formula |
C15H17N5O4 |
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CAS No. |
1191237-80-5 |
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Appearance |
Solid |
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Color |
Off-white to light yellow |
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SMILES |
N#C[C@](O1)(C2=CC=C3N2N=CN=C3N)[C@@](OC4(C)C)(04)[C@@](O4)(04)[C@H]1CO |
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Shipping | Room temperature in continental US; may vary elsewhere. |
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Storage |
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Solvent & Solubility |
In Vitro:
DMSO : 100 mg/mL (301.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Purity & Documentation |
Purity: 99.88% |
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References |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO | 1 mM | 3.0181 mL | 15.0907 mL | 30.1814 mL | 75.4535 mL |
5 mM | 0.6036 mL | 3.0181 mL | 6.0363 mL | 15.0907 mL | |
10 mM | 0.3018 mL | 1.5091 mL | 3.0181 mL | 7.5453 mL | |
15 mM | 0.2012 mL | 1.0060 mL | 2.0121 mL | 5.0302 mL | |
20 mM | 0.1509 mL | 0.7545 mL | 1.5091 mL | 3.7727 mL | |
25 mM | 0.1207 mL | 0.6036 mL | 1.2073 mL | 3.0181 mL | |
30 mM | 0.1006 mL | 0.5030 mL | 1.0060 mL | 2.5151 mL | |
40 mM | 0.0755 mL | 0.3773 mL | 0.7545 mL | 1.8863 mL | |
50 mM | 0.0604 mL | 0.3018 mL | 0.6036 mL | 1.5091 mL | |
60 mM | 0.0503 mL | 0.2515 mL | 0.5030 mL | 1.2576 mL | |
80 mM | 0.0377 mL | 0.1886 mL | 0.3773 mL | 0.9432 mL | |
100 mM | 0.0302 mL | 0.1509 mL | 0.3018 mL | 0.7545 mL |