Acarbose [56180-94-0]
Cat# HY-B0089-1g
Size : 1g
Brand : MedChemExpress
Acarbose (BAY g 5421), antihyperglycemic agent, is an orally active alpha-glucosidase inhibitor (IC50=11 nM). Acarbose can potentiate the hypoglycemic effects of sulfonylureas or insulin.
For research use only. We do not sell to patients.
Acarbose Chemical Structure
CAS No. : 56180-94-0
This product is a controlled substance and not for sale in your territory.
Based on 3 publication(s) in Google Scholar
Other Forms of Acarbose:
- Acarbose sulfate Get quote
Description |
Acarbose (BAY g 5421), antihyperglycemic agent, is an orally active alpha-glucosidase inhibitor (IC50=11 nM). Acarbose can potentiate the hypoglycemic effects of sulfonylureas or insulin[1][2][3]. |
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In Vitro |
Acarbose (1, 2, and 3 μM) dose- and time-dependently inhibits TNF-α-induced VSMC proliferation and migration. Acarbose (1, 2, and 3 μM) dose-dependently decreases β-galactosidase, Ras expression and increased p-AMPK expression in TNF-α pre-treated A7r5 cells[5]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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In Vivo |
Acarbose (300 mg/60 kg body weight) decreases the fasting blood glucose, and regulates the glucose tolerance of DM rats without body weight loss. Acarbose significantly suppresses serum IL6 and TNF-α in DM rats[4]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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Clinical Trial |
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Molecular Weight |
645.60 |
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Formula |
C25H43NO18 |
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CAS No. |
56180-94-0 |
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Appearance |
Solid |
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Color |
White to light yellow |
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SMILES |
OC[C@H]([C@]1(O[C@@H]2[C@H](O)[C@@H](O)[C@@H]([C@H](O2)C)N[C@]3(C=C(CO)[C@H]([C@@H]([C@H]3O)O)O)22)22)O[C@@H]([C@@H]([C@H]1O)O)O[C@@](22)([C@@H]([C@H](C=O)O)O)[C@@H](CO)O |
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Structure Classification |
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Initial Source |
Actinoplanes sp |
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Shipping | Room temperature in continental US; may vary elsewhere. |
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Storage |
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Solvent & Solubility |
In Vitro:
H2O : 100 mg/mL (154.89 mM; Need ultrasonic) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles. * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
For the following dissolution methods, please prepare the working solution directly.
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration:
mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
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Purity & Documentation | |||||||||||||
References |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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H2O | 1 mM | 1.5489 mL | 7.7447 mL | 15.4895 mL | 38.7237 mL |
5 mM | 0.3098 mL | 1.5489 mL | 3.0979 mL | 7.7447 mL | |
10 mM | 0.1549 mL | 0.7745 mL | 1.5489 mL | 3.8724 mL | |
15 mM | 0.1033 mL | 0.5163 mL | 1.0326 mL | 2.5816 mL | |
20 mM | 0.0774 mL | 0.3872 mL | 0.7745 mL | 1.9362 mL | |
25 mM | 0.0620 mL | 0.3098 mL | 0.6196 mL | 1.5489 mL | |
30 mM | 0.0516 mL | 0.2582 mL | 0.5163 mL | 1.2908 mL | |
40 mM | 0.0387 mL | 0.1936 mL | 0.3872 mL | 0.9681 mL | |
50 mM | 0.0310 mL | 0.1549 mL | 0.3098 mL | 0.7745 mL | |
60 mM | 0.0258 mL | 0.1291 mL | 0.2582 mL | 0.6454 mL | |
80 mM | 0.0194 mL | 0.0968 mL | 0.1936 mL | 0.4840 mL | |
100 mM | 0.0155 mL | 0.0774 mL | 0.1549 mL | 0.3872 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.