Reagents and instruments for immunology, cell biology and molecular biology.
 
> AG 555 [133550-34-2]

AG 555 [133550-34-2]

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Cat# VD-IS-0047-10mg

Size : 10mg

Brand : VDM Biochemicals


Product Specification

  • Appearance
    :

    Yellow solid

  • CAS Number
    :

    133550-34-2

  • Cat.number
    :

    VD-IS-0047

  • Formula
    :

    C19H18N2O3

  • MW
    :

    322.36

  • Purity
    :

    ≥98% by HPLC

  • Solubility
    :

    30 mM in DMSO, EtOH.

  • Storage
    :

    -20°C. Protect from light.

  • Synonyms
    :

    Tyrphostin AG 555

  • Size
    :

    10mg, 50mg

SKU: VD-IS-0047 Categories: Cancer, Intracellular Signaling

Description

AG 555 (CAS 133550-34-2) is a potent epidermal growth factor receptor (EGFR) kinase inhibitor (IC50 = 0.7 μM) that displays 50-fold and >140-fold selectivity over ErbB2 and insulin receptor kinase respectively. Induce G1 growth arrest selectively in transformed cells (IC50 values are 6.4 and 9.4 μM in HPV16-immortalized and normal keratinocytes respectively).

1. Gazit et al (1991) J.Med.Chem. 34 1896.
2. Levitzki and Gazit (1995) Science 267 1782.
3. Ben-Bassat et al (1999) J.Pharmacol.Exp.Ther. 290 1442.