General Info
Host: | Rabbit |
Applications: | WB/IF/ELISA |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-Phospho-Estrogen receptor beta-Ser105 (71-120 aa) is suitable for use in Western Blot, Immunofluorescence and ELISA research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration: | 1 mg/mL |
Dilution Range: | WB 1:500-1:2000IF 1:200-1:1000ELISA 1:5000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
Gene Symbol: | ESR2 |
Gene ID: | 2100 |
Uniprot ID: | ESR2_HUMAN |
Immunogen Region: | 71-120 aa |
Specificity: | Phospho-ER Beta (S105) Polyclonal Antibody detects endogenous levels of ER Beta protein only when phosphorylated at S105. |
Immunogen: | The antiserum was produced against synthesized peptide derived from the human Estrogen Receptor-beta around the phosphorylation site of Ser105 at the amino acid range 71-120 |
Description
Post Translational Modifications | Phosphorylation at Ser-87 and Ser-105 recruits NCOA1. |
Function | Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform 2: Lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability. |
Protein Name | Estrogen Receptor BetaEr-BetaNuclear Receptor Subfamily 3 Group A Member 2 |
Database Links | Reactome: R-HSA-1257604Reactome: R-HSA-2219530Reactome: R-HSA-383280Reactome: R-HSA-6811558Reactome: R-HSA-8939211Reactome: R-HSA-9009391 |
Cellular Localisation | Nucleus |
Alternative Antibody Names | Anti-Estrogen Receptor Beta antibodyAnti-Er-Beta antibodyAnti-Nuclear Receptor Subfamily 3 Group A Member 2 antibodyAnti-ESR2 antibodyAnti-ESTRB antibodyAnti-NR3A2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance