General Info
Host: | Rabbit |
Applications: | WB |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit monoclonal antibody anti-Plexin A1 (100-200) is suitable for use in Western Blot research applications. |
Clonality: | Monoclonal |
Clone ID: | S1MR |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
Purification: | Affinity purification |
Dilution Range: | WB 1:500-1:1000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
Gene Symbol: | PLXNA1 |
Gene ID: | 5361 |
Uniprot ID: | PLXA1_HUMAN |
Immunogen Region: | 100-200 |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human Plexin A1 (Q9UIW2). |
Immunogen Sequence: | SVQSCPHGLGSTDNVNKLLL LDYAANRLLACGSASQGICQ FLRLDDLFKLGEPHHRKEHY LSSVQEAGSMAGVLIAGPPG QGQAKLFVGTPIDGKSEYFP T |
Description
Tissue Specificity | Detected in fetal brain, lung, liver and kidney. |
Function | Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. |
Protein Name | Plexin-A1Semaphorin Receptor Nov |
Database Links | Reactome: R-HSA-399954Reactome: R-HSA-399955Reactome: R-HSA-399956Reactome: R-HSA-416700Reactome: R-HSA-9013405Reactome: R-HSA-9696273 |
Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
Alternative Antibody Names | Anti-Plexin-A1 antibodyAnti-Semaphorin Receptor Nov antibodyAnti-PLXNA1 antibodyAnti-NOV antibodyAnti-PLXN1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance