Anti-TLR7 antibody (175-225) {Biotin}

Cat# NB-22-60134-100

Size : 100ug

Brand : Neo Biotech


General Info

Host: Rabbit
Applications: ELISA/WB
Reactivity: Cat/Human/Mouse/Pig
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-TLR7 (175-225) is suitable for use in ELISA and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Biotin
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.65-0.72 µg/µl
Dilution Range: WB: 1:500
DB: 1:20, 000
ELISA: 1:20, 000
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Information

Gene Symbol: TLR7
Gene ID: 51284
Uniprot ID: TLR7_HUMAN
Immunogen Region: 175-225
Immunogen: Synthetic peptide taken within amino acid region 175-225 on human TLR7 protein.

Description

Tissue Specificity Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells. Expressed in peripheral mononuclear blood cells.
Function Endosomal receptor that plays a key role in innate and adaptive immunity. Controls host immune response against pathogens through recognition of uridine-containing single strand RNAs (ssRNAs) of viral origin or guanosine analogs. Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction. In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce pro-inflammatory cytokines and interferons, respectively.
Protein Name Toll-Like Receptor 7
Database Links Reactome: R-HSA-1679131
Reactome: R-HSA-168181
Reactome: R-HSA-9679191
Reactome: R-HSA-9692916
Reactome: R-HSA-9705671
Reactome: R-HSA-975110
Reactome: R-HSA-975138
Reactome: R-HSA-975155
Cellular Localisation Endoplasmic Reticulum Membrane
Single-Pass Type I Membrane Protein
Endosome
Lysosome
Cytoplasmic Vesicle
Phagosome
Relocalizes From Endoplasmic Reticulum To Endosome And Lysosome Upon Stimulation With Agonist
Alternative Antibody Names Anti-Toll-Like Receptor 7 antibody
Anti-TLR7 antibody
Anti-UNQ248 antibody
Anti-PRO285 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance