General Info
| Applications: | ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 0.129ng/mL |
| Detection Limit: | 0.312-20ng/mL |
| Short Description: | This CACNa1B Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 4.5 hrs |
Information
| Gene Symbol: | CACNA1B |
| Gene ID: | 774 |
| Uniprot ID: | CAC1B_HUMAN |
| Sample Type: | tissue homogenates, cell lysates or other biological fluids. |
Description
| Tissue Specificity | Isoform Alpha-1b-1 and isoform Alpha-1b-2 are expressed in the central nervous system, but not in skeletal muscle or aorta. Expressed in the cerebral white matter, cortex, hippocampus, basal ganglia, and cerebellum. |
| Post Translational Modifications | Phosphorylated in vitro by CaM-kinase II, PKA, PKC and CGPK. |
| Function | Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This alpha-1B subunit gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group. They are involved in pain signaling. Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons. Mediates Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals. |
| Protein Name | Voltage-Dependent N-Type Calcium Channel Subunit Alpha-1bBrain Calcium Channel IiiBiiiCalcium Channel - L Type - Alpha-1 Polypeptide Isoform 5Voltage-Gated Calcium Channel Subunit Alpha Cav2.2 |
| Database Links | Reactome: R-HSA-112308 |
| Cellular Localisation | MembraneMulti-Pass Membrane Protein |
| Alternative ELISA Names | Voltage-Dependent N-Type Calcium Channel Subunit Alpha-1b ELISA kitBrain Calcium Channel Iii ELISA kitBiii ELISA kitCalcium Channel - L Type - Alpha-1 Polypeptide Isoform 5 ELISA kitVoltage-Gated Calcium Channel Subunit Alpha Cav2.2 ELISA kitCACNA1B ELISA kitCACH5 ELISA kitCACNL1A5 ELISA kit |
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Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance