Human CD44 (CD44) Sandwich ELISA Kit E0001896)

Conjugation:	Biotin
Storage Instruction:	Unopened kits can be stored at 2-8°C for 1 year, and opened products must be used within 1 month.
Assay Time:	4 hours
Detection:	Colorimetric

Gene Symbol:	CD44
Gene ID:	960
Uniprot ID:	CD44_HUMAN
Sample Type:	serum, plasma and cell culture supernates

Tissue Specificity	Detected in fibroblasts and urine (at protein level). Detected in placenta (at protein level). Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells.
Post Translational Modifications	Proteolytically cleaved in the extracellular matrix by specific proteinases (possibly MMPs) in several cell lines and tumors. N-glycosylated. O-glycosylated.contains chondroitin sulfate glycans which can be more or less sulfated and whose number may affect the accessibility of specific proteinases to their cleavage site(s). It is uncertain if O-glycosylation occurs on Thr-637 or Thr-638. Phosphorylated.activation of PKC results in the dephosphorylation of Ser-706 (constitutive phosphorylation site), and the phosphorylation of Ser-672.
Function	Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment. Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection. Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases. Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion.
Protein Name	Cd44 Antigen Cdw44 Epican Extracellular Matrix Receptor Iii Ecmr-Iii Gp90 Lymphocyte Homing/Adhesion Receptor Hutch-I Heparan Sulfate Proteoglycan Hermes Antigen Hyaluronate Receptor Phagocytic Glycoprotein 1 Pgp-1 Phagocytic Glycoprotein I Pgp-I Cd Antigen Cd44
Database Links	Reactome: R-HSA-1474228 Reactome: R-HSA-202733 Reactome: R-HSA-216083 Reactome: R-HSA-2160916 Reactome: R-HSA-6798695 Reactome: R-HSA-877300
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein Cell Projection Microvillus Secreted Colocalizes With Actin In Membrane Protrusions At Wounding Edges Co-Localizes With Rdx Ezr And Msn In Microvilli Localizes To Cholesterol-Rich Membrane-Bound Lipid Raft Domains
Alternative ELISA Names	Cd44 Antigen ELISA kit Cdw44 ELISA kit Epican ELISA kit Extracellular Matrix Receptor Iii ELISA kit Ecmr-Iii ELISA kit Gp90 Lymphocyte Homing/Adhesion Receptor ELISA kit Hutch-I ELISA kit Heparan Sulfate Proteoglycan ELISA kit Hermes Antigen ELISA kit Hyaluronate Receptor ELISA kit Phagocytic Glycoprotein 1 ELISA kit Pgp-1 ELISA kit Phagocytic Glycoprotein I ELISA kit Pgp-I ELISA kit Cd Antigen Cd44 ELISA kit CD44 ELISA kit LHR ELISA kit MDU2 ELISA kit MDU3 ELISA kit MIC4 ELISA kit
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Information sourced from Uniprot.org

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