Methyl linolenate [301-00-8]
Cat# HY-21268-200mg
Size : 200mg
Brand : MedChemExpress
Methyl linolenate is a polyunsaturated fattly acid (PUFA). Methyl linolenate has an anti-melanogenesis activity with an IC50 of 60 μM. Methyl linolenate can also be used for studies of the mechanisms and prevention of oxidation/peroxidation of unsaturated fatty acids.
For research use only. We do not sell to patients.
Methyl linolenate Chemical Structure
CAS No. : 301-00-8
This product is a controlled substance and not for sale in your territory.
Based on 1 publication(s) in Google Scholar
Other Forms of Methyl linolenate:
- Methyl linolenate-13C18 Get quote
Description |
Methyl linolenate is a polyunsaturated fattly acid (PUFA). Methyl linolenate has an anti-melanogenesis activity with an IC50 of 60 μM. Methyl linolenate can also be used for studies of the mechanisms and prevention of oxidation/peroxidation of unsaturated fatty acids[1][2][3][4]. |
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In Vitro |
Methyl linolenate (50, 100 μM, 48 h) significantly down-regulates microphthalmia-associated transcription factor (MITF) and tyrosinase-related proteins in B16F10 cells[4]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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Molecular Weight |
292.46 |
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Formula |
C19H32O2 |
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CAS No. |
301-00-8 |
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Unlabeled CAS |
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Appearance |
Liquid |
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Color |
Colorless to light yellow |
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SMILES |
CC/C=C\C/C=C\C/C=C\CCCCCCCC(OC)=O |
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Structure Classification |
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Initial Source |
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Shipping | Room temperature in continental US; may vary elsewhere. |
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Storage |
-20°C, protect from light, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen) |
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Solvent & Solubility |
In Vitro:
DMSO : 100 mg/mL (341.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Purity & Documentation |
Purity: 99.68% |
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References |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO | 1 mM | 3.4193 mL | 17.0964 mL | 34.1927 mL | 85.4818 mL |
5 mM | 0.6839 mL | 3.4193 mL | 6.8385 mL | 17.0964 mL | |
10 mM | 0.3419 mL | 1.7096 mL | 3.4193 mL | 8.5482 mL | |
15 mM | 0.2280 mL | 1.1398 mL | 2.2795 mL | 5.6988 mL | |
20 mM | 0.1710 mL | 0.8548 mL | 1.7096 mL | 4.2741 mL | |
25 mM | 0.1368 mL | 0.6839 mL | 1.3677 mL | 3.4193 mL | |
30 mM | 0.1140 mL | 0.5699 mL | 1.1398 mL | 2.8494 mL | |
40 mM | 0.0855 mL | 0.4274 mL | 0.8548 mL | 2.1370 mL | |
50 mM | 0.0684 mL | 0.3419 mL | 0.6839 mL | 1.7096 mL | |
60 mM | 0.0570 mL | 0.2849 mL | 0.5699 mL | 1.4247 mL | |
80 mM | 0.0427 mL | 0.2137 mL | 0.4274 mL | 1.0685 mL | |
100 mM | 0.0342 mL | 0.1710 mL | 0.3419 mL | 0.8548 mL |