Rabbit Polyclonal Anti-CD8A (Cytotoxic- & Suppressor T-Cell Marker) Polyclonal Antibody
Cat# 24-925-RBP4-1ml
Size : 1ml
Brand : American Research Products
Anti-CD8A (Cytotoxic- & Suppressor T-Cell Marker), Monoclonal Antibody
Category: Antibodies
Catalog
24-925-RBP4
| Product Name | Anti-CD8A (Cytotoxic- & Suppressor T-Cell Marker), Monoclonal Antibody |
|---|---|
| Description | CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 β chain (CD8 α/β) or as a homodimer (CD8 α/α). A majority of thymocytes and a subpopulation of mature T cells and NK cell express CD8a. CD8 binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells. For mature T-cells, CD4 and CD8 are mutually exclusive, so anti-CD8, generally used in conjunction with anti-CD4. It is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral T-cell lymphomas are CD4+/CD8-. Anaplastic large cell lymphoma is usually CD4+ and CD8-, and in T-lymphoblastic lymphoma/leukemia, CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen. |
| Synonyms | CD8 antigen, alpha polypeptide (p32), T8/Leu-2 T-lymphocyte differentiation antigen, Ly3, LYT3, MAL, T-cell surface glycoprotein CD8 alpha chain |
| Host | Rabbit |
| Clonality | Monoclonal |
| Immunogen | Human CD8 recombinant fragment corresponding to aa 200-250 |
| Isotype | IgG |
| Reactivity | Human |
| Applications | FC, IF |
| Form | 200_g/ml of antibody purified from rabbit anti-serum by Protein A chromatography. Supplied in 10mM PBS, pH 7.4 with 0.05% BSA and 0.05% sodium azide. Contact us if you require this antibody in a different format. |
| Gene Id | 925 |
| Uniprot | P01732 |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody is stable for 24 months. ,Non-hazardous. No MSDS required. |
| References | Mason DY, et. al. Journal of Clinical Pathology, 1992, 45(12):1084-8 |
| Supplier | ARP |
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