Seclidemstat (mesylate) [2044953-70-8]
Cat# HY-103713A-100mg
Size : 100mg
Brand : MedChemExpress
Seclidemstat (SP-2577) mesylate is a potent noncompetitive and reversible KDM1A (LSD1) inhibitor (Ki=31 nM, IC50=13 nM). Seclidemstat mesylate promotes antitumor immunity in switch/sucrose nonfermentable (SWI/SNF) complex mutated ovarian cancer, as well as inhibit virus production, viral DNA replication, and late gene expression. Seclidemstat mesylate can be used for the research of Ewing Sarcoma.
For research use only. We do not sell to patients.
Seclidemstat mesylate Chemical Structure
CAS No. : 2044953-70-8
This product is a controlled substance and not for sale in your territory.
Based on 4 publication(s) in Google Scholar
Other Forms of Seclidemstat mesylate:
- Seclidemstat In-stock
| Description |
Seclidemstat (SP-2577) mesylate is a potent noncompetitive and reversible KDM1A (LSD1) inhibitor (Ki=31 nM, IC50=13 nM). Seclidemstat mesylate promotes antitumor immunity in switch/sucrose nonfermentable (SWI/SNF) complex mutated ovarian cancer, as well as inhibit virus production, viral DNA replication, and late gene expression. Seclidemstat mesylate can be used for the research of Ewing Sarcoma[1][2]. |
IC50 & Target |
Ki: 31 nM (LSD1)[1] |
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| In Vitro |
Seclidemstat (72 hours) mesylate inhibits SWI/SNF-mutation-dependent tumor cell proliferation with IC50 ranging from 0.013 to 2.819 μM (COV434, BIN67, SCCOHT-1, TOV21G, SKOV3, A427, H522, A549, H1299, G401, G402, HCC15 cells)[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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| Clinical Trial |
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| Molecular Weight |
547.04 |
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| Formula |
C21H27ClN4O7S2 |
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| CAS No. |
2044953-70-8 |
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| Appearance |
Solid |
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| Color |
Off-white to light yellow |
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| SMILES |
O=C(N/N=C(C1=CC(Cl)=CC=C1O)\C)C2=CC=CC(S(=O)(N3CCN(C)CC3)=O)=C2.CS(O)(=O)=O |
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| Shipping | Room temperature in continental US; may vary elsewhere. |
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| Storage |
4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
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| Solvent & Solubility |
In Vitro:
DMSO : 53.33 mg/mL (97.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) H2O : < 0.1 mg/mL (insoluble) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration:
mg/mL
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| Purity & Documentation |
Purity: 99.86% |
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| References |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.8280 mL | 9.1401 mL | 18.2802 mL | 45.7005 mL |
| 5 mM | 0.3656 mL | 1.8280 mL | 3.6560 mL | 9.1401 mL | |
| 10 mM | 0.1828 mL | 0.9140 mL | 1.8280 mL | 4.5700 mL | |
| 15 mM | 0.1219 mL | 0.6093 mL | 1.2187 mL | 3.0467 mL | |
| 20 mM | 0.0914 mL | 0.4570 mL | 0.9140 mL | 2.2850 mL | |
| 25 mM | 0.0731 mL | 0.3656 mL | 0.7312 mL | 1.8280 mL | |
| 30 mM | 0.0609 mL | 0.3047 mL | 0.6093 mL | 1.5233 mL | |
| 40 mM | 0.0457 mL | 0.2285 mL | 0.4570 mL | 1.1425 mL | |
| 50 mM | 0.0366 mL | 0.1828 mL | 0.3656 mL | 0.9140 mL | |
| 60 mM | 0.0305 mL | 0.1523 mL | 0.3047 mL | 0.7617 mL | |
| 80 mM | 0.0229 mL | 0.1143 mL | 0.2285 mL | 0.5713 mL |