Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO at 100 mg/mL; soluble in ethanol at 2.5 mg/mL with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-20 µM; buffers, serum, or other additives may increase or decrease the aqueous solubili. Disposal: A.

• July 27, 2023:  we expect our next  lot of  Staurosporine, Free Base to be ready to ship during the week of August 7, 2023.
• More than 930 labs worldwide have purchased Staurosporine from LC Labs (either directly from us or from our many distributors, many of whom resell under their own labels).
• CHECK THE PRICES!
  

           SIGMA - 1 mg - $928
           EMD Chemicals - 1 mg - $599
           LabSeeker - 1 mg - $2934

• SMART: Buy just 1 mg of staurosporine from LC Labs instead of Sigma; with the money you save, you can buy a new pH meter or about 40,000 pipet tips!
• SMARTER: Buy 100-300 mg from LC Labs; support a postdoc for 1-2 years with the money you save!
• Staurosporine is a potent inhibitor of many, many kinases including protein kinase C (IC50 = 0.7 nM), protein kinase A (IC50 = 7 nM), and protein kinase G (IC50 = 8.5 nM). Matsumoto, H. and Sasaki, Y. "Staurosporine, a protein kinase C inhibitor, interferes with proliferation of arterial smooth muscle cells." Biochem. Biophys. Res. Commun. 158: 105-109 (1989). Tamaoki, T., et al. "Staurosporine, a potent inhibitor of phospholipid/Ca++dependent protein kinase." Biochem. Biophys. Res. Commun. 135: 397-402 (1986).
• Staurosporine induces apoptosis in human neuroblastoma cell lines and chick embryonic neurons. Boix, J., et al. "Characterization of the cell death process induced by staurosporine in human neuroblastoma cell lines." Neuropharmacology 36: 811-821 (1997). Wiesner, D.A. and Dawson, G., "Staurosporine induces programmed cell death in embryonic neurons and activation of the ceramide pathway." J. Neurochem. 66: 1418-1425 (1996).
• Please request Technical Note #24 for additional information.
• Sold for laboratory or manufacturing purposes only; not for human, medical, veterinary, food, or household use.