General Info
Host: | Mouse |
Applications: | FC |
Reactivity: | Mouse |
Note: | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Short Description: | Mouse monoclonal antibody anti-Receptor-type tyrosine-protein phosphatase C is suitable for use in Flow Cytometry research applications. |
Clonality: | Monoclonal |
Clone ID: | 104.2 |
Conjugation: | APC |
Isotype: | IgG2ak |
Formulation: | PBS with 0.05% Proclin300, 1% BSA |
Storage Instruction: | Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product. |
Information
Gene Symbol: | Ptprc |
Gene ID: | 19264 |
Uniprot ID: | PTPRC_MOUSE |
Description
Post Translational Modifications | Heavily N- and O-glycosylated. |
Function | Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity. |
Protein Name | Receptor-Type Tyrosine-Protein Phosphatase CLeukocyte Common AntigenL-CaLymphocyte Antigen 5Ly-5T200Cd Antigen Cd45 |
Database Links | Reactome: R-MMU-202427Reactome: -MMU-416700Reactome: -MMU-6798695 |
Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinMembrane RaftColocalized With Dpp4 In Membrane Rafts |
Alternative Antibody Names | Anti-Receptor-Type Tyrosine-Protein Phosphatase C antibodyAnti-Leukocyte Common Antigen antibodyAnti-L-Ca antibodyAnti-Lymphocyte Antigen 5 antibodyAnti-Ly-5 antibodyAnti-T200 antibodyAnti-Cd Antigen Cd45 antibodyAnti-Ptprc antibodyAnti-Ly-5 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance