β-Hydroxyisovaleric Acid-d8

Cat# 469713-10mg

Size : 10mg

Brand : US Biological



469713 β-Hydroxyisovaleric Acid-d8

Clone Type
Polyclonal
Grade
Highly Purified
Shipping Temp
RT
Storage Temp
4°C

β-Hydroxyisovaleric Acid-d8 is the isotope labeled analog of β-Hydroxyisovaleric Acid; a metabolite of the essential amino acid Leucine. It is synthesized in the human body and studies suggest that β-Hydroxyisovaleric Acid may have an effect on increasing muscle weight and strength. The presence of elevated β-Hydroxyisovaleric Acid is a sensitive marker of biotin deficiency and may indicate the presence of a genetic disorder such as biotinidase deficiency or holocarboxylase synthetase deficiency.||Synonyms:|3-Hydroxy-3-methylbutanoic Acid-d8; 3-Hydroxy-3-methylbutyric Acid-d8; 3-Hydroxyisovaleric Acid-d8; β-Hydroxy-β-methylbutyric Acid-d8||CAS No:|123743-99-7|Unlabeled: 625-08-1||Molecular Formula:|C₅H₂D₈O₃||Molecular Weight:|126.18||Purity:|≥97% (Isotopic)||Appearance:|Colorless to yellow oil||Solubility:|DMSO (Sparingly), Methanol (Slightly)||Method for Determining Identity:|H NMR and C NMR Spectrometric Analysis and Mass Spectrometric Analysis||TLC Conditions:|SiO2; Dichloromethane: Methanol: Acetic Acid=8:1:0.1; Visualized with AMCS; Single Spot, Rf=0.65||Normalized Intensity:|d0=0.00%, d1=0.00%, d2=0.01%, d3=0.03%, d4=0.00%, d5=0.07%, d6=0.31%, d7=4.48%, d8=95.10%||Storage and Stability:|May be stored at RT for short-term only. Long-term storage is recommended at 4ºC for 6 months after time of receipt.

Applications
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. ||Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.
References
1. Nissen, S. et al.: J. Appl. Physiol., 81, 2095 (1996). 2. Wilson, G.J. et al.: Nutrit. Metab., 5, 1 (2008). 3. Mock, D.M. et al.: Am. J. Clin. Nutrit., 76, 1061 (2002)

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