General Info
Host: | Rabbit |
Applications: | WB/IHC/IF |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-RCE1 (100-200) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
Purification: | Affinity purification |
Dilution Range: | WB 1:500-1:2000IHC-P 1:50-1:200IF/ICC 1:50-1:200 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
Gene Symbol: | RCE1 |
Gene ID: | 9986 |
Uniprot ID: | FACE2_HUMAN |
Immunogen Region: | 100-200 |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human RCE1 (NP_005124.1). |
Immunogen Sequence: | SLLTLMGFRLEGIFPAALLP LLLTMILFLGPLMQLSMDCP CDLADGLKVVLAPRSWARCL TDMRWLRNQVIAPLTEELVF RACMLPMLAPCMGLGPAVFT C |
Description
Tissue Specificity | Ubiquitous. |
Post Translational Modifications | Ubiquitinated. Undergoes 'Lys-48'- and 'Lys-63'-linked ubiquitination. 'Lys-48' ubiquitination induces its degradation. Deubiquitinated by USP17L2/USP17 that cleaves 'Lys-63'-linked ubiquitin chains. |
Function | Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins. Seems to be able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1. |
Protein Name | Caax Prenyl Protease 2Farnesylated Proteins-Converting Enzyme 2Face-2Prenyl Protein-Specific Endoprotease 2Rce1 HomologHrce1 |
Database Links | Reactome: R-HSA-5689880Reactome: R-HSA-9648002 |
Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
Alternative Antibody Names | Anti-Caax Prenyl Protease 2 antibodyAnti-Farnesylated Proteins-Converting Enzyme 2 antibodyAnti-Face-2 antibodyAnti-Prenyl Protein-Specific Endoprotease 2 antibodyAnti-Rce1 Homolog antibodyAnti-Hrce1 antibodyAnti-RCE1 antibodyAnti-FACE2 antibodyAnti-RCE1A antibodyAnti-RCE1B antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance