Anti-HSP70 Monoclonal Antibody (Clone : 3A3) - ATTO 390
Figure1 : Mouse Anti-HSP70 Antibody [3A3] used in Immunocytochemistry/Immunofluorescence (ICC/IF) on Human Cervical Cancer cell line (HeLa)
Size : 100ug
Figure1 : Mouse Anti-HSP70 Antibody [3A3] used in Immunocytochemistry/Immunofluorescence (ICC/IF) on Human Cervical Cancer cell line (HeLa)
Amount : | 100 µg |
Isotype : | Mouse IgG1 |
Purification : | Protein G Purified |
Content : | PBS pH7.2, 50% glycerol, 0.09% sodium azide |
Storage condition : | Store the antibody at 4°C |
WB (1:5000), ICC/IF (1:500), IP (2µg); optimal dilutions for assays should be determined by the user.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
Subcellular location: | Cytoplasm, Nucleus, Cytoplasm |
Post transnational modification: | In response to cellular stress, acetylated at Lys-77 by NA110 and then gradually deacetylated by HDAC4 at later stages. Acetylation enhances its chaperone activity and also determines whether it will function as a chaperone for protein refolding or degradation by controlling its binding to co-chaperones HOPX and STUB1. The acetylated form and the non-acetylated form bind to HOPX and STUB1 respectively. Acetylation also protects cells against various types of cellular stress. |
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