Candesartan Cilexetil (TCV-116) is an angiotensin II receptor inhibitor. Candesartan Cilexetil ameliorates the pulmonary fibrosis and has antiviral and skin wound healing effect. Candesartan Cilexetil can be used for the research of high blood pressure^{[1][2][3][4][5][6]}.

Candesartan Cilexetil (0.1-10 μM, 24 h) exhibits antiviral effects against ZIKV in HUVEC cells, HEK293T cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Candesartan Cilexetil (5 mg/kg, Oral gavage, once a day for 7 weeks) ameliorates myocardial remodeling and heart failure in Dahl salt-sensitive (DS) rats fed a high-salt diet^[2].
Candesartan Cilexetil (1-10 mg/kg, Oral, once a day for 15 days) has an effect of skin wound healing in rats^[3].
Candesartan Cilexetil (1-10 mg/kg, Administered through a stomach tube, once a day for 4-12 weeks) inhibits the increase in blood pressure in spontaneously hypertensive rats^[5].
Candesartan Cilexetil (10 mg/kg, Oral, supplemented in drinking water, for 2-23 days) inhibits the synthesis of TGF-b1 and ameliorates the pulmonary fibrosis in bleomycin (HY-108345) induced pulmonary fibrosis model rats^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

610.66

C₃₃H₃₄N₆O₆

145040-37-5

Solid

White to off-white

O=C(C1=C2C(N=C(OCC)N2CC3=CC=C(C4=CC=CC=C4C5=NNN=N5)C=C3)=CC=C1)OC(OC(OC6CCCCC6)=O)C

Room temperature in continental US; may vary elsewhere.

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

• [1]. Loe M W C, et al. Antiviral activity of the FDA-approved drug candesartan cilexetil against Zika virus infection [J]. Antiviral Research, 2019, 172: 104637.  [Content Brief]

  [2]. Kobayashi N, et al. Effects of TCV-116 on expression of NOS and adrenomedullin in failing heart of Dahl salt-sensitive rats [J]. Atherosclerosis, 2001, 156(2): 255-265.  [Content Brief]

  [3]. Takeda H, et al. Effects of angiotensin II receptor signaling during skin wound healing [J]. The American journal of pathology, 2004, 165(5): 1653-1662.  [Content Brief]

  [4]. McClellan K J, et al. Candesartan cilexetil: a review of its use in essential hypertension [J]. Drugs, 1998, 56: 847-869.  [Content Brief]

  [5]. Kojima M, et al. Angiotensin II receptor antagonist TCV-116 induces regression of hypertensive left ventricular hypertrophy in vivo and inhibits the intracellular signaling pathway of stretch-mediated cardiomyocyte hypertrophy in vitro [J]. Circulation, 1994, 89(5): 2204-2211.  [Content Brief]

  [6]. Otsuka M, et al. Reduction of bleomycin induced lung fibrosis by candesartan cilexetil, an angiotensin II type 1 receptor antagonist [J]. Thorax, 2004, 59(1): 31-38.  [Content Brief]