Cefuroxime (sodium) [56238-63-2]
Cat# HY-B1256-1ml
Size : 10mM/1mL
Brand : MedChemExpress
Cefuroxime sodium is an orally active second-generation cephalosporin antibiotic with increased stability to β-lactamase. Cefuroxime sodium has a broad spectrum activity against Gram-positive and Gram-negative bacteria.
For research use only. We do not sell to patients.
Cefuroxime sodium Chemical Structure
CAS No. : 56238-63-2
This product is a controlled substance and not for sale in your territory.
Based on 4 publication(s) in Google Scholar
Other Forms of Cefuroxime sodium:
- Cefuroxime In-stock
- Cefuroxime axetil In-stock
- Cefuroxime-d3 Get quote
View All Beta-lactamase Isoform Specific Products:
View All Antibiotic Isoform Specific Products:
Description |
Cefuroxime sodium is an orally active second-generation cephalosporin antibiotic with increased stability to β-lactamase. Cefuroxime sodium has a broad spectrum activity against Gram-positive and Gram-negative bacteria[1]. |
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IC50 & Target |
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In Vitro |
Cefuroxime sodium is highly active against S. aureus (MIC=0.25 μg/ml), regardless of whether the strains produces a penicillinase. It is against Staphylococcus aureus methicillin susceptible; S. aureus, methicillin resistant, Streptococcus pyogenes, S. pneumoniae, S. viridans, S. faecalis, and Clostridium spp with MIC values of 0.25 μg/ml, 5.9 μg/ml, 0.125 μg/ml, 0.125 μg/ml, 0.125 μg/ml, >125.0 μg/ml, and 1.2 μg/ml, respectively[1].Cefuroxime sodium (10-100 μg/ml; 2-6 hours) rapidly bactericidal, its action is comparatively slow against the strains of S. aureus, but, even so, over 99% of the initial inoculum is killed by 6 h. The gram-negative organisms are killed rapidly, and in most cases over 99% of the very large inocula are killed within 2 h; the β-lactamase-producing strains are killed as quickly as non-enzyme-producing strains[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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In Vivo |
Rabbits (weighing 2.0 to 2.5 kg) are challenged intravenously with S. aureus strain 630 (a penicillinase-producing strain), the median effective dose of Cefuroxime sodium is 3 mg/kg as a result of the protection test[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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Clinical Trial |
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Molecular Weight |
446.37 |
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Formula |
C16H15N4NaO8S |
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CAS No. |
56238-63-2 |
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Unlabeled CAS |
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Appearance |
Solid |
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Color |
White to off-white |
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SMILES |
O=C(C(N12)=C(COC(N)=O)CS[C@]2(21)[C@H](NC(/C(C3=CC=CO3)=N\OC)=O)C1=O)O[Na] |
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Shipping | Room temperature in continental US; may vary elsewhere. |
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Storage |
4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
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Solvent & Solubility |
In Vitro:
DMSO : ≥ 100 mg/mL (224.03 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) H2O : 50 mg/mL (112.01 mM; Need ultrasonic) *"≥" means soluble, but saturation unknown. Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
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Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles. * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
For the following dissolution methods, please prepare the working solution directly.
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration:
mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
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Purity & Documentation |
Purity: 99.46% |
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References |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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H2O / DMSO | 1 mM | 2.2403 mL | 11.2015 mL | 22.4029 mL | 56.0073 mL |
5 mM | 0.4481 mL | 2.2403 mL | 4.4806 mL | 11.2015 mL | |
10 mM | 0.2240 mL | 1.1201 mL | 2.2403 mL | 5.6007 mL | |
15 mM | 0.1494 mL | 0.7468 mL | 1.4935 mL | 3.7338 mL | |
20 mM | 0.1120 mL | 0.5601 mL | 1.1201 mL | 2.8004 mL | |
25 mM | 0.0896 mL | 0.4481 mL | 0.8961 mL | 2.2403 mL | |
30 mM | 0.0747 mL | 0.3734 mL | 0.7468 mL | 1.8669 mL | |
40 mM | 0.0560 mL | 0.2800 mL | 0.5601 mL | 1.4002 mL | |
50 mM | 0.0448 mL | 0.2240 mL | 0.4481 mL | 1.1201 mL | |
60 mM | 0.0373 mL | 0.1867 mL | 0.3734 mL | 0.9335 mL | |
80 mM | 0.0280 mL | 0.1400 mL | 0.2800 mL | 0.7001 mL | |
100 mM | 0.0224 mL | 0.1120 mL | 0.2240 mL | 0.5601 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.