Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Isolithocholic Acid [1534-35-6]
Cat# T35792-5mg
Size : 5mg
Brand : TargetMol
Isolithocholic Acid
Catalog No. T35792 CAS 1534-35-6
Synonyms: 3-Epilithocholic acid, 3β-Hydroxy-5β-cholanic acid, β-Lithocholic acid, isoLCA
Isolithocholic Acid (3-Epilithocholic acid) (β-Lithocholic acid) is an isomer of Lithocholic acid. Isolithocholic Acid, a bile acid, is formed by microbial metabolism of Lithocholic acid or Lithocholic acid 3α-sulfate.
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Isolithocholic Acid, CAS 1534-35-6
| Description | Isolithocholic Acid (3-Epilithocholic acid) (β-Lithocholic acid) is an isomer of Lithocholic acid. Isolithocholic Acid, a bile acid, is formed by microbial metabolism of Lithocholic acid or Lithocholic acid 3α-sulfate. |
| In vitro | Isolithocholic Acid at a concentration of 0.01% does not inhibit the spore germination and outgrowth in CF5 and M120 strains, but at a higher concentration of 0.1%, it significantly inhibits these processes. At a much lower concentration (0.00003%), it prevents the growth of CD196, M68, CF5, 630, and BI9 strains, while also substantially reducing toxin activity in CF5, BI9, M120, and 630 strains. Furthermore, a slightly higher concentration of Isolithocholic Acid (0.0003%) results in a significant decrease in toxin activity across all strains, with the exception of R20291 and M120[3]. |
| In vivo | Fecal Isolithocholic Acid levels significantly decrease starting from day 28 in the high fat diet (HFD) group when compared to rats on a normal diet[4]. |
| Synonyms | 3-Epilithocholic acid, 3β-Hydroxy-5β-cholanic acid, β-Lithocholic acid, isoLCA |
| Molecular Weight | 376.57 |
| Formula | C24H40O3 |
| CAS No. | 1534-35-6 |
Storage
Solubility Information
Chloroform: Slightly soluble
Ethanol: Slightly soluble
Methanol: Slightly soluble
DMSO: 4.4 mg/mL (11.68 mM)
References and Literature
1. Batta, A.K., Salen, G., and Shefer, S.Transformation of bile acids into iso-bile acids by Clostridium perfringes: Possible transport of 3β-hydrogen via the coenzymeHepatology5(6)1126-1131(1985) 2. Borriello, S.P., and Owen, R.W.The metabolism of lithocholic acid and lithocholic acid-3-α-sulfate by human fecal bacteriaLipids17(7)477-482(1982) 3. Thanissery, R., Winston, J.A., and Theriot, C.M.Inhibition of spore germination, growth, and toxin activity of clinically relevant C. difficile strains by gut microbiota derived secondary bile acidsAnaerobe4586-100(2017) 4. Lin, H., An, Y., Tang, H., et al.Alterations of bile acids and gut microbiota in obesity induced by high fat diet in rat modelJ. Agric. Food Chem.67(13)3624-3632(2019)