Isotretinoin [4759-48-2]
Cat# HY-15127-500mg
Size : 500mg
Brand : MedChemExpress
Isotretinoin (13-cis-Retinoic acid) is an orally active vitamin A derivative and is often be used for the research of severe acne. Isotretinoin also shows anticancer activity.
For research use only. We do not sell to patients.
Isotretinoin Chemical Structure
CAS No. : 4759-48-2
This product is a controlled substance and not for sale in your territory.
Based on 4 publication(s) in Google Scholar
Other Forms of Isotretinoin:
- Isotretinoin-d5 Get quote
Description |
Isotretinoin (13-cis-Retinoic acid) is an orally active vitamin A derivative and is often be used for the research of severe acne. Isotretinoin also shows anticancer activity[1][2]. |
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IC50 & Target[2] |
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In Vitro |
Isotretinoin (13-cis-Retinoic acid) may act as a pro-drug that is converted intracellularly to metabolites that are agonists for RAR and RXR nuclear receptors[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assay[4]
RT-PCR[4]
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In Vivo |
Isotretinoin (13-cis-Retinoic acid) (1.3-481 μg/L; inhalation exposure; 45 min daily for 2 weeks) is an effective lung cancer chemopreventive agent in A/J Mice[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Clinical Trial |
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Molecular Weight |
300.44 |
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Formula |
C20H28O2 |
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CAS No. |
4759-48-2 |
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Appearance |
Solid |
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Color |
Yellow to orange |
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SMILES |
CC1(C)C(/C=C/C(C)=C/C=C/C(C)=C\C(O)=O)=C(C)CCC1 |
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Structure Classification |
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Initial Source |
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Shipping | Room temperature in continental US; may vary elsewhere. |
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Storage |
-20°C, protect from light, stored under nitrogen *The compound is unstable in solutions, freshly prepared is recommended. |
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Solvent & Solubility |
In Vitro:
DMSO : 100 mg/mL (332.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
*The compound is unstable in solutions, freshly prepared is recommended.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Purity & Documentation | |||||||||||||||||
References |
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Complete Stock Solution Preparation Table
* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO | 1 mM | 3.3285 mL | 16.6423 mL | 33.2845 mL | 83.2113 mL |
5 mM | 0.6657 mL | 3.3285 mL | 6.6569 mL | 16.6423 mL | |
10 mM | 0.3328 mL | 1.6642 mL | 3.3285 mL | 8.3211 mL | |
15 mM | 0.2219 mL | 1.1095 mL | 2.2190 mL | 5.5474 mL | |
20 mM | 0.1664 mL | 0.8321 mL | 1.6642 mL | 4.1606 mL | |
25 mM | 0.1331 mL | 0.6657 mL | 1.3314 mL | 3.3285 mL | |
30 mM | 0.1109 mL | 0.5547 mL | 1.1095 mL | 2.7737 mL | |
40 mM | 0.0832 mL | 0.4161 mL | 0.8321 mL | 2.0803 mL | |
50 mM | 0.0666 mL | 0.3328 mL | 0.6657 mL | 1.6642 mL | |
60 mM | 0.0555 mL | 0.2774 mL | 0.5547 mL | 1.3869 mL | |
80 mM | 0.0416 mL | 0.2080 mL | 0.4161 mL | 1.0401 mL | |
100 mM | 0.0333 mL | 0.1664 mL | 0.3328 mL | 0.8321 mL |