Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ISX-9 [832115-62-5]
Cat# T2003-10mg
Size : 10mg
Brand : TargetMol
ISX-9
Catalog No. T2003 CAS 832115-62-5
Synonyms: Isoxazole 9, Isoxazole 9 (ISX-9)
ISX-9 (Isoxazole 9) is necessary to activate neuron-specific genes as neurogenesis inducer.
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ISX-9, CAS 832115-62-5
| Description | ISX-9 (Isoxazole 9) is necessary to activate neuron-specific genes as neurogenesis inducer. |
| In vitro | In NSPCs, isoxazole 9 increases cell number, and promotes cell differentiation. In OPCs, isoxazole 9 induces cell damage. In outgrowth EPCs, isoxazole 9 decreases tube formation without effect on early EPCs. [1] |
| In vivo | In mice, isoxazole 9 (20 mg/kg, i.p.) crosses the BBB and increases proliferation of neuroblasts and neurogenesis via Mef2-specific mechanisms in the hippocampal SGZ. Isoxazole 9 (20 mg/kg, i.p.) also increases differentiation and dendritic complexity of immature neurons and improves memory. In MWM, isoxazole 9 improves spatial memory. [2] |
| Cell Research | Cells are treated with different concentrations of Isx-9 (0, 6.25, 12.5, 25, or 50 μM), and 2 days later, cell numbers are counted in a blinded manner to evaluate the effects of Isx-9 on the proliferation/survival of four types of progenitor/precursor cells.(Only for Reference) |
| Synonyms | Isoxazole 9, Isoxazole 9 (ISX-9) |
| Molecular Weight | 234.27 |
| Formula | C11H10N2O2S |
| CAS No. | 832115-62-5 |
Storage
Solubility Information
Ethanol: 11 mg/mL (47 mM)
DMSO: 43 mg/mL (183.5 mM)
References and Literature
1. Koh SH, et al. PLoS One. 2015, 10(9), e0138724. 2. Petrik D, et al. FASEB J. 2012, 26(8), 3148-3162.