Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Miglitol [72432-03-2]
Cat# T1529-200mg
Size : 200mg
Brand : TargetMol
Miglitol
Catalog No. T1529 CAS 72432-03-2
Synonyms: BAY1099, BAY-m1099
Miglitol (BAY1099) is an alpha-Glucosidase Inhibitor with antihyperglycemic activity.
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Miglitol, CAS 72432-03-2
| Description | Miglitol (BAY1099) is an alpha-Glucosidase Inhibitor with antihyperglycemic activity. |
| In vivo | D-cycloserine (DCS) facilitates extinction of conditioned freezing to the light CS when no drug pre-exposure has occurred, but pre-exposure to DCS just prior to conditioning disrupted the facilitation of extinction effect in mice. [1] D-cycloserine (DCS) which has a high affinity for the glycine modulatory site in the NMDA receptor complex modulated memory processing in a dose-dependent manner. DCS also facilitates retention in 'senescence-accelerated mice' in which impairment of learning andmemory increases with age. [2] D-cycloserine (DCS) exhibits facilitated extinction of fear but are able to reacquire fear of that conditioned stimulus (CS) in a similar manner as saline-treated control rats. DCS-treated rats exhibits generalized extinction (i.e., they are less fearful of a non-extinguished CS) in comparison to controls. [3] D-cycloserine (DCS), an antimycobacterial agent known to cross the blood-brain barrier, binds with high affinity to this glycine modulatory site, functions as a positive modulator, and facilitates performance of learningtasks in rats. DCS appears to be a potent cognitive enhancer at doses lower than those required for antibacterial activity. [4] D-cycloserine injections (3.25, 15, or 30 mg/kg) before 30 non-reinforced light exposures dose-dependently enhances extinction but does not influence fear-potentiated startle in rats that does not receive extinction training. [5] |
| Synonyms | BAY1099, BAY-m1099 |
| Molecular Weight | 207.22 |
| Formula | C8H17NO5 |
| CAS No. | 72432-03-2 |
Storage
Solubility Information
H2O: 20.7 mg/mL (100 mM)
DMSO: 20.7 mg/mL (100 mM)
References and Literature
1. Rossi EJ, et al. FEBS J. 2006 Jun;273(12):2673-83. 2. Liu T, Liu R, Zhu L, et al. Development of a UHPLC-MS method for inhibitor screening against α-L-1, 3-fucosidase[J]. Analytical and bioanalytical chemistry. 2019 Mar;411(7):1467-1477.