Naproxen etemesil [385800-16-8]
Cat# HY-19675-50mg
Size : 50mg
Brand : MedChemExpress
Naproxen etemesil is a lipophilic, non-acidic, inactive proagent of naproxen that is hydrolysed to pharmacologically active Naproxen once absorbed. Naproxen is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively in cell assay.
For research use only. We do not sell to patients.
Naproxen etemesil Chemical Structure
CAS No. : 385800-16-8
This product is a controlled substance and not for sale in your territory.
Based on 1 publication(s) in Google Scholar
Other Forms of Naproxen etemesil:
- Naproxen sodium In-stock
Description |
Naproxen etemesil is a lipophilic, non-acidic, inactive proagent of naproxen that is hydrolysed to pharmacologically active Naproxen once absorbed. Naproxen is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively in cell assay. |
IC50 & Target |
IC50: 8.72 μM (COX-1), 5.15 μM (COX-2)[1] |
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In Vitro |
Naproxen etemesil is a lipophilic, non-acidic, inactive prodrug of naproxen that is hydrolysed to pharmacologically active Naproxen once absorbed. Naproxen is a well known nonsteroidal anti-inflammatory drug. Naproxen is approximately equipotent inhibitor of COX-1 and COX-2 in intact cells with IC50s of 2.2 μg/mL and 1.3 μg/mL, respectively[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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In Vivo |
Naproxen exerts an anti-inflammatory and antifibrotic effect in mouse model of bleomycin-induced lung fibrosis. Naproxen also downregulates TGF-β levels and Smad3/4 complex formation[2]. Naproxen is shown to inhibit the time-courses of pain, fever and PGE2 with similar potencies (IC50=27, 40, 13 μM)[3]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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Molecular Weight |
336.40 |
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Formula |
C17H20O5S |
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CAS No. |
385800-16-8 |
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Appearance |
Solid |
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Color |
White to off-white |
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SMILES |
O=C(OCCS(C)(=O)=O)[C@@H](C)C1=CC2=CC=C(OC)C=C2C=C1 |
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Shipping | Room temperature in continental US; may vary elsewhere. |
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Storage |
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Solvent & Solubility |
In Vitro:
DMSO : 100 mg/mL (297.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Purity & Documentation |
Purity: 99.89% |
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References |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO | 1 mM | 2.9727 mL | 14.8633 mL | 29.7265 mL | 74.3163 mL |
5 mM | 0.5945 mL | 2.9727 mL | 5.9453 mL | 14.8633 mL | |
10 mM | 0.2973 mL | 1.4863 mL | 2.9727 mL | 7.4316 mL | |
15 mM | 0.1982 mL | 0.9909 mL | 1.9818 mL | 4.9544 mL | |
20 mM | 0.1486 mL | 0.7432 mL | 1.4863 mL | 3.7158 mL | |
25 mM | 0.1189 mL | 0.5945 mL | 1.1891 mL | 2.9727 mL | |
30 mM | 0.0991 mL | 0.4954 mL | 0.9909 mL | 2.4772 mL | |
40 mM | 0.0743 mL | 0.3716 mL | 0.7432 mL | 1.8579 mL | |
50 mM | 0.0595 mL | 0.2973 mL | 0.5945 mL | 1.4863 mL | |
60 mM | 0.0495 mL | 0.2477 mL | 0.4954 mL | 1.2386 mL | |
80 mM | 0.0372 mL | 0.1858 mL | 0.3716 mL | 0.9290 mL | |
100 mM | 0.0297 mL | 0.1486 mL | 0.2973 mL | 0.7432 mL |