Protirelin [24305-27-9]
Cat# HY-P0002-10mg
Size : 10mg
Brand : MedChemExpress
Protirelin is a highly conserved neuropeptide that exerts the hormonal control of thyroid-stimulating hormone (TSH) levels as well as neuromodulatory functions.
For research use only. We do not sell to patients.
Custom Peptide Synthesis
Protirelin Chemical Structure
CAS No. : 24305-27-9
This product is a controlled substance and not for sale in your territory.
Based on 1 publication(s) in Google Scholar
Other Forms of Protirelin:
- Protirelin acetate In-stock
- Thyrotropin-Releasing Hormone (TRH), Free Acid In-stock
Description |
Protirelin is a highly conserved neuropeptide that exerts the hormonal control of thyroid-stimulating hormone (TSH) levels as well as neuromodulatory functions. |
IC50 & Target |
Thyroid hormone receptor |
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In Vivo |
Protirelin (TRH) is an evolutionarily ancient neuropeptide, having its origin before the divergence of protostomes and deuterostomes, and may ancestrally have been involved in the control of postembryonic growth and reproduction[1]. The effect of the thyrotropin-releasing hormone (Protirelin, TRH), one of the hypothalamic releasing hormones, on body temperature is investigated in the rat. Protirelin, in doses of 1, 5, 10 and 20 mg/kg, is injected intraperitoneally to male Wistar rats weighing 200-250 g. Protirelin causes a temporary rise in body temperature dose-dependently. The thyroidectomized rats injected 20 mg/kg of Protirelin which induces a significant hyperthermia in the sham-operated animals, fail to show a rise in body temperature. The present results suggest that a release of thyroid hormone might participate in the hyperthermic action of Protirelin[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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Molecular Weight |
362.38 |
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Formula |
C16H22N6O4 |
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CAS No. |
24305-27-9 |
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Appearance |
Solid |
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Color |
White to off-white |
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Sequence |
{pGlu}-His-Pro-NH2 |
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Sequence Shortening |
{pGlu}-HP-NH2 |
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Structure Classification |
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Initial Source |
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Shipping | Room temperature in continental US; may vary elsewhere. |
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Storage |
Sealed storage, away from moisture and light
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
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Solvent & Solubility |
In Vitro:
DMSO : 250 mg/mL (689.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
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Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration:
mg/mL
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Purity & Documentation | |||||||||||||
References |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO | 1 mM | 2.7595 mL | 13.7977 mL | 27.5953 mL | 68.9884 mL |
5 mM | 0.5519 mL | 2.7595 mL | 5.5191 mL | 13.7977 mL | |
10 mM | 0.2760 mL | 1.3798 mL | 2.7595 mL | 6.8988 mL | |
15 mM | 0.1840 mL | 0.9198 mL | 1.8397 mL | 4.5992 mL | |
20 mM | 0.1380 mL | 0.6899 mL | 1.3798 mL | 3.4494 mL | |
25 mM | 0.1104 mL | 0.5519 mL | 1.1038 mL | 2.7595 mL | |
30 mM | 0.0920 mL | 0.4599 mL | 0.9198 mL | 2.2996 mL | |
40 mM | 0.0690 mL | 0.3449 mL | 0.6899 mL | 1.7247 mL | |
50 mM | 0.0552 mL | 0.2760 mL | 0.5519 mL | 1.3798 mL | |
60 mM | 0.0460 mL | 0.2300 mL | 0.4599 mL | 1.1498 mL | |
80 mM | 0.0345 mL | 0.1725 mL | 0.3449 mL | 0.8624 mL | |
100 mM | 0.0276 mL | 0.1380 mL | 0.2760 mL | 0.6899 mL |