trans-Zeatin [1637-39-4]
Cat# HY-19700-10mg
Size : 10mg
Brand : MedChemExpress
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trans-Zeatin is a plant cytokinin, which plays an important role in cell growth, differentiation, and division; trans-Zeatin also inhibits UV-induced MEK/ERK activation.
For research use only. We do not sell to patients.
trans-Zeatin Chemical Structure
CAS No. : 1637-39-4
Size | Price | Stock | Quantity |
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Free Sample (0.1 - 0.5 mg) | Apply Now | ||
5 mg | USD 32 | In-stock | |
10 mg | USD 50 | In-stock | |
50 mg | USD 80 | In-stock | |
100 mg | Get quote | ||
200 mg | Get quote |
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This product is a controlled substance and not for sale in your territory.
Customer Review
Based on 1 publication(s) in Google Scholar
Other Forms of trans-Zeatin:
- trans-Zeatin-d5 In-stock
1 Publications Citing Use of MCE trans-Zeatin
View All MEK Isoform Specific Products:
View All ERK Isoform Specific Products:
Biological Activity
Purity & Documentation
References
Customer Review
Description |
trans-Zeatin is a plant cytokinin, which plays an important role in cell growth, differentiation, and division; trans-Zeatin also inhibits UV-induced MEK/ERK activation. |
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IC50 & Target[2] |
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In Vitro |
trans-Zeatin is a plant cytokinin, which plays an important role in cell growth, differentiation, and division[1]. trans-Zeatin (20, 40 or 80 μM) inhibits UV-induced MEK/ERK activation, upregulates AQP3 in a time- and dose-dependent manner, and attenuates UV induced loss of AQP3 in keratinocytes (HaCaT cells). UV-induced AQP3 downregulation is blocked by MEK/ERK inhibitors. Trans-Zeatin (80 μM) attenuates UV-induced downregulation of wound healing and water permeability in HaCaT cells[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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Molecular Weight |
219.24 |
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Formula |
C10H13N5O |
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CAS No. | |||||||||||||
Appearance |
Solid |
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Color |
White to off-white |
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SMILES |
OC/C(C)=C/CNC1=C2N=CNC2=NC=N1 |
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Structure Classification | |||||||||||||
Initial Source | |||||||||||||
Shipping | Room temperature in continental US; may vary elsewhere. |
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Storage |
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Solvent & Solubility |
In Vitro:
DMSO : 25 mg/mL (114.03 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Purity & Documentation | |||||||||||||
References |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO | 1 mM | 4.5612 mL | 22.8061 mL | 45.6121 mL | 114.0303 mL |
5 mM | 0.9122 mL | 4.5612 mL | 9.1224 mL | 22.8061 mL | |
10 mM | 0.4561 mL | 2.2806 mL | 4.5612 mL | 11.4030 mL | |
15 mM | 0.3041 mL | 1.5204 mL | 3.0408 mL | 7.6020 mL | |
20 mM | 0.2281 mL | 1.1403 mL | 2.2806 mL | 5.7015 mL | |
25 mM | 0.1824 mL | 0.9122 mL | 1.8245 mL | 4.5612 mL | |
30 mM | 0.1520 mL | 0.7602 mL | 1.5204 mL | 3.8010 mL | |
40 mM | 0.1140 mL | 0.5702 mL | 1.1403 mL | 2.8508 mL | |
50 mM | 0.0912 mL | 0.4561 mL | 0.9122 mL | 2.2806 mL | |
60 mM | 0.0760 mL | 0.3801 mL | 0.7602 mL | 1.9005 mL | |
80 mM | 0.0570 mL | 0.2851 mL | 0.5702 mL | 1.4254 mL | |
100 mM | 0.0456 mL | 0.2281 mL | 0.4561 mL | 1.1403 mL |
trans-Zeatin Related Classifications
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Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.
Keywords:
trans-Zeatin1637-39-4MEKERKEndogenous MetaboliteMitogen-activated protein kinase kinaseMAPKKMAP2KExtracellular signal regulated kinasesInhibitorinhibitorinhibit
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