Specifications

Product Data
Applications	IHC, WB
Recommended Dilution	WB: 1000-5000 WB positive control: Human leiomyosarcoma and mouse testis tissue IHC: 25-100 Positive control: Human liver cancer Predicted cell location: Cytoplasm
Reactivities	Human, Mouse, Rat
Host	Rabbit
Isotype	IgG
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 270-284 amino acids of human tropomyosin 2 (beta)
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage	Store at -20°C as received.
Stability	Stable for 12 months from date of receipt.
Predicted Protein Size	33 kDa
Gene Name	tropomyosin 2 (beta)
Database Link	NP_003280 Entrez Gene 22004 MouseEntrez Gene 500450 RatEntrez Gene 7169 Human UniProt ID P07951
Background	This gene encodes beta-tropomyosin; a member of the actin filament binding protein family; and mainly expressed in slow; type 1 muscle fibers. Mutations in this gene can alter the expression of other sarcomeric tropomyosin proteins; and cause cap disease; nemaline myopathy and distal arthrogryposis syndromes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms	AMCD1; DA1; DA2B; HEL-S-273; NEM4; TMSB
Reference Data
Protein Pathways	Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM)