Catestatin (Chromogranin A) (Rhodamine)

Cat# C2096-86E6-100ul

Size : 100ul

Brand : US Biological



C2096-86E6 Catestatin (Chromogranin A) (Rhodamine)

Clone Type
Polyclonal
Host
rabbit
Source
rat
Isotype
IgG
Grade
Purified
Applications
FLISA
Crossreactivity
Rt
Shipping Temp
Blue Ice
Storage Temp
-20°C

Catestatin is a 21-amino acid residue, cationic and hydrophobic peptide that is formed endogenously by proteolytic cleavage of its precursor chromogranin A, a major protein co-stored and co-released with catecholamines from the storage vesicles in adrenal chromaffin cells and adrenergic neurons. This peptide exhibits potent catecholamine release-inhibitory activity by acting on the neuronal nicotinic acetylcholine receptor. It also stimulates histamine release from mast cells via heterotrimeric G-proteins in a receptor-independent manner. Plasma levels of catestatin are diminished not only in hypertensive patients but also in their still-normotensive offspring, indicating its role in the pathogenesis of hypertension. Consistently, exogenous catestatin rescues hypertension in chromogranin A knockout mice and diminishes blood pressure responses to activation of sympathetic outflow in rats. These hypotensive actions of catestatin may be caused directly by autocrine inhibition of catecholamine release from the sympathoadrenal system and indirectly by paracrine stimulation of the potent vasodilator histamine release from mast cells. Recently, three human variants of catestatin displaying differential potencies for inhibition of catecholamine secretion have been identified. One of these variants (Gly364Ser) causes increased baroreceptor sensitivity, increased cardiac parasympathetic activity, and decreased cardiac sympathetic activity, and it seems to alter the risk for hypertension. These cardiovascular effects may have resulted by action of this peptide in the baroreceptor centre of the nucleus tractus solitarius. Thus, accumulating evidence documents the endogenous peptide catestatin as a novel regulator of cardiac function and blood pressure.||Applications:|Suitable for use in FLISA. Other applications not tested.||Recommended Dilution:|Optimal dilutions to be determined by the researcher.||Storage and Stability:|May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Rhodamine Labeled product is light sensitive.

Applications
Product Type: Pab|Isotype: IgG|Host: rabbit|Source: rat|Concentration: Not determined|Form: Supplied as a liquid. Labeled with Rhodamine.|Purity: Purified|Immunogen: Synthetic peptide corresponding to rat Catestatin.|Specificity: Recognizes rat Catestatin.||Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Immunogen
Synthetic peptide corresponding to rat Catestatin.
Form
Supplied as a liquid. Labeled with Rhodamine.
Purity
Purified
Specificity
Recognizes rat Catestatin.
References
1. Mahapatra, N.R., Cardiovasc. Res. 80(3): 330-338 (2008).