Lipopeptoid with antifungal activity against Cryptococcus neoformans; Peptoids.
Form/Appearance
Freeze dried solid
Purity
96.2% by hplc
MW
521.7 Da
Formula
C28H51N5O4
Ntri-NLys-Nfur
Solubility (25°C)
> 50 mg per ml in water
For more information about peptoids and their nomenclature please refer to the resources section.
Antifungals
Protein Sequence
Ntri-NLys-Nfur
Storage
Store dry, frozen and in the dark
Alternative names
AEC5antifungal, lipopeptoid, peptoid
Background
AEC5 is a trimeric lipopeptoid with potent antifungal activity against Cryptococcus neoformans and Cryptococcus gattii and modest efficacy against other microbial pathogens. AEC5 rapidly reduces fungal burden in infected macrophages against C. neoformans, with nearly 50% reduction in fungal growth after 30 minutes and complete elimination of viable fungi within 3 hours. In mouse models AEC5 has an in vivo half-life of >20 hours and no observable toxicity following 28 days of daily injections.
